Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM456613

Substrate/Competitor

n/a

Meas. Tech.

GTPγS Binding

EC50

8.30±n/a nM

Citation

Brown, M; Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Houze, J; Kayser, F; Khakoo, AY; Kopecky, D; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yeh, W Triazole furan compounds as agonists of the APJ receptor US Patent US10736883 Publication Date 8/11/2020

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM456613

n/a

Name

BDBM456613

Synonyms:

US10736883, Example 54.0

Type

Small organic molecule

Emp. Form.

C22H25N5O7S

Mol. Mass.

503.528

SMILES

COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](O)c2coc(C)n2)nnc1-c1ccc(C)o1 |r,wU:16.17,wD:18.19,(.9,6.78,;-.43,6.01,;-1.77,6.78,;-1.77,8.32,;-3.1,9.09,;-4.44,8.32,;-4.43,6.78,;-5.77,6.01,;-7.1,6.78,;-3.1,6.01,;-3.1,4.47,;-1.85,3.57,;-.52,4.34,;.82,3.57,;2.15,2.8,;-.52,2.8,;2.15,4.34,;2.15,5.88,;3.48,3.57,;3.48,2.03,;4.82,4.34,;4.98,5.87,;6.48,6.19,;7.25,4.85,;8.79,4.69,;6.22,3.71,;-2.33,2.1,;-3.87,2.1,;-4.34,3.56,;-5.81,4.04,;-6.29,5.5,;-7.83,5.5,;-8.3,4.04,;-9.76,3.56,;-7.05,3.13,)|

Structure