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TargetPotassium channel subfamily K member 9
LigandBDBM458963
Substrate/Competitorn/a
Meas. Tech.Inhibition In Vito Assay
IC50 1.04±0.23 nM
Citation Delbeck, MHahn, MMüller, TMeier, HLustig, KMosig, JToschi, LAlbus, UGehring, DRosenstein, B 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders US Patent US10759794 Publication Date 9/1/2020
More Info.:Get all data from this article,  Assay Method
 
Potassium channel subfamily K member 9
Name:Potassium channel subfamily K member 9
Synonyms:Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2
Type:PROTEIN
Mol. Mass.:42276.04
Organism:Homo sapiens (Human)
Description:ChEMBL_1457494
Residue:374
Sequence:
MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM458963
n/a
NameBDBM458963
Synonyms:(4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(cyclopentyl)methanone | US10759794, Example 1
TypeSmall organic molecule
Emp. Form.C24H27BrN4O
Mol. Mass.467.401
SMILESBrc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1
Structure
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