| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 9 |
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| Ligand | BDBM458963 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition In Vito Assay |
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| IC50 | 1.04±0.23 nM |
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| Citation |  Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders US Patent US10759794 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 9 |
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| Name: | Potassium channel subfamily K member 9 |
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| Synonyms: | Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42276.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457494 |
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| Residue: | 374 |
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| Sequence: | MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
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| BDBM458963 |
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| n/a |
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| Name | BDBM458963 |
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| Synonyms: | (4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(cyclopentyl)methanone | US10759794, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27BrN4O |
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| Mol. Mass. | 467.401 |
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| SMILES | Brc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 |
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| Structure | 
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