| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 3 |
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| Ligand | BDBM458965 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition In Vito Assay |
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| IC50 | 4.20±0.6 nM |
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| Citation |  Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders US Patent US10759794 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 3 |
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| Name: | Potassium channel subfamily K member 3 |
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| Synonyms: | Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1 |
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| Type: | Protein |
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| Mol. Mass.: | 43534.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14649 |
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| Residue: | 394 |
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| Sequence: | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
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| BDBM458965 |
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| n/a |
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| Name | BDBM458965 |
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| Synonyms: | (4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(6-methoxypyridin-2-yl)methanone | US10759794, Example 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24ClN5O2 |
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| Mol. Mass. | 461.943 |
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| SMILES | COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 |
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| Structure | 
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