Reaction Details |
| Report a problem with these data |
Target | Potassium channel subfamily K member 9 |
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Ligand | BDBM459029 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition In Vito Assay |
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IC50 | 9.40±n/a nM |
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Citation | Delbeck, M; Hahn, M; Müller, T; Meier, H; Lustig, K; Mosig, J; Toschi, L; Albus, U; Gehring, D; Rosenstein, B 2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders US Patent US10759794 Publication Date 9/1/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Potassium channel subfamily K member 9 |
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Name: | Potassium channel subfamily K member 9 |
Synonyms: | Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2 |
Type: | PROTEIN |
Mol. Mass.: | 42276.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1457494 |
Residue: | 374 |
Sequence: | MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
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BDBM459029 |
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n/a |
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Name | BDBM459029 |
Synonyms: | (4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl) [6-(trifluoromethoxy)pyridin-2-yl]methanone | US10759794, Example 67 |
Type | Small organic molecule |
Emp. Form. | C25H21ClF3N5O2 |
Mol. Mass. | 515.915 |
SMILES | FC(F)(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 |
Structure |
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