| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 [403-822] |
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| Ligand | BDBM350034 |
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| Substrate/Competitor | n/a |
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| IC50 | 1.80±n/a nM |
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| Citation |  Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 2 [403-822] |
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| Name: | Fibroblast growth factor receptor 2 [403-822] |
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| Synonyms: | BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(403-822) | KGFR | KSAM |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47577.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 403-822 |
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| Residue: | 420 |
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| Sequence: | NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA
GVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP
PGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK
IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG
SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL
TLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
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| BDBM350034 |
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| n/a |
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| Name | BDBM350034 |
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| Synonyms: | US10208024, Example 33 | US10766881, Example 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N8O4 |
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| Mol. Mass. | 532.5942 |
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| SMILES | COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1 |
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| Structure | 
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