| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 [403-822] |
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| Ligand | BDBM350049 |
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| Substrate/Competitor | n/a |
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| IC50 | 1.000±n/a nM |
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| Citation |  Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 2 [403-822] |
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| Name: | Fibroblast growth factor receptor 2 [403-822] |
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| Synonyms: | BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(403-822) | KGFR | KSAM |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47577.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 403-822 |
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| Residue: | 420 |
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| Sequence: | NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA
GVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD
DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP
PGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK
IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG
SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL
TLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
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| BDBM350049 |
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| n/a |
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| Name | BDBM350049 |
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| Synonyms: | 6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2-yl)-4-cyclopropyl-2- (3,5- dimethoxyphenyl)pyridazin- 3(2H)-one | US10208024, Example 48 | US10766881, Example 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N7O3 |
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| Mol. Mass. | 445.4738 |
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| SMILES | COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1 |
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| Structure | 
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