Ki Summary

Reaction Details

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Target

Fibroblast growth factor receptor 3 [397-806]

Ligand

BDBM350059

Substrate/Competitor

n/a

IC50

0.700±n/a nM

Citation

Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020

More Info.:

Get all data from this article, Assay Method

Fibroblast growth factor receptor 3 [397-806]

Name:

Fibroblast growth factor receptor 3 [397-806]

Synonyms:

FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

45431.04

Organism:

Homo sapiens (Human)

Description:

P22607[397-806]

Residue:

410

Sequence:

RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE
LELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD
KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLD
YSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADF
GLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP
GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS
TDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT

BDBM350059

n/a

Name

BDBM350059

Synonyms:

US10208024, Example 58 | US10766881, Example 58

Type

Small organic molecule

Emp. Form.

C25H25Cl2N7O3

Mol. Mass.

542.417

SMILES

COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 |(6.08,3.85,;7.42,3.08,;7.42,1.54,;8.75,.77,;8.75,-.77,;10.08,-1.54,;10.08,-3.08,;7.42,-1.54,;7.42,-3.08,;6.08,-.77,;6.08,.77,;4.75,1.54,;4.75,-1.54,;3.42,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;.75,-.77,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-.58,1.54,;.75,.77,;2.08,1.54,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-4.72,-1.06,;-7.11,-1.91,;-7.51,-.42,;-9,-.03,;-10.08,-1.11,;-9.69,-2.6,;-8.2,-3,)|

Structure