Ki Summary

Reaction Details

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Target

Fibroblast growth factor receptor 1 [308-731]

Ligand

BDBM350083

Substrate/Competitor

n/a

Meas. Tech.

LanthaScreen Assay

IC50

2.40±n/a nM

Citation

Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020

More Info.:

Get all data from this article, Assay Method

Fibroblast growth factor receptor 1 [308-731]

Name:

Fibroblast growth factor receptor 1 [308-731]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

47326.25

Organism:

Homo sapiens (Human)

Description:

aa 308-731

Residue:

424

Sequence:

VQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPA
VMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQV
TVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEG
CFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL
LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV
ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWM
APEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTN
ELYM

BDBM350083

n/a

Name

BDBM350083

Synonyms:

US10208024, Example 82 | US10766881, Example 82

Type

Small organic molecule

Emp. Form.

C27H30F2N8O4

Mol. Mass.

568.5751

SMILES

COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)|

Structure