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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 3 [397-806] | ||
| Ligand | BDBM350083 | ||
| Substrate/Competitor | n/a | ||
| IC50 | 2.20±n/a nM | ||
| Citation |  Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent US10766881 Publication Date 9/8/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 3 [397-806] | |||
| Name: | Fibroblast growth factor receptor 3 [397-806] | ||
| Synonyms: | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 45431.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P22607[397-806] | ||
| Residue: | 410 | ||
| Sequence: |
| ||
| BDBM350083 | |||
| n/a | |||
| Name | BDBM350083 | ||
| Synonyms: | US10208024, Example 82 | US10766881, Example 82 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H30F2N8O4 | ||
| Mol. Mass. | 568.5751 | ||
| SMILES | COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1c(F)c(OC)cc(OC)c1F |(-13.14,-4.41,;-12.37,-3.08,;-10.83,-3.08,;-10.06,-1.75,;-8.52,-1.75,;-7.75,-.41,;-6.21,-.41,;-5.44,-1.75,;-6.21,-3.08,;-7.75,-3.08,;-3.9,-1.75,;-3,-.5,;-1.53,-.98,;-1.53,-2.52,;-3,-2.99,;-.2,-.21,;-.2,1.33,;1.14,2.1,;2.47,1.33,;3.8,2.1,;2.47,-.21,;1.14,-.98,;3.8,-.98,;3.8,-2.52,;5.14,-3.29,;6.47,-2.52,;7.81,-3.29,;6.47,-.98,;5.14,-.21,;7.81,-.21,;9.14,-.98,;9.14,-2.52,;10.47,-.21,;11.81,-.98,;13.14,-.21,;10.47,1.33,;9.14,2.1,;9.14,3.64,;10.47,4.41,;7.81,1.33,;6.47,2.1,)| | ||
| Structure | 
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