| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM486405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DGAT2 Enzymatic Activity Assay |
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| IC50 | 61.0±n/a nM |
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| Citation |  Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10947222 Publication Date 3/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM486405 |
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| n/a |
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| Name | BDBM486405 |
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| Synonyms: | 3-biphenyl-3-yl-N-(1,1- dioxidotetrahydrothiophen-3-yl)- 1-(4-fluorophenyl)-1H-indole-6- carboxamide (racemic) | US10947222, Example 36 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H25FN2O3S |
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| Mol. Mass. | 524.605 |
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| SMILES | Fc1ccc(cc1)-n1cc(-c2cccc(c2)-c2ccccc2)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |
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| Structure | 
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