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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 2 | ||
| Ligand | BDBM486419 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DGAT2 Enzymatic Activity Assay | ||
| IC50 | 155±n/a nM | ||
| Citation |  Shen, D; Graham, TH; Jiang, J; Ding, F; Tudge, C Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10947222 Publication Date 3/16/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 2 | |||
| Name: | Diacylglycerol O-acyltransferase 2 | ||
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 43848.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96PD7 | ||
| Residue: | 388 | ||
| Sequence: |
| ||
| BDBM486419 | |||
| n/a | |||
| Name | BDBM486419 | ||
| Synonyms: | 3-(2-chloro-6-fluorophenyl)-N- (1,1-dioxidotetrahydrothiophen-3- yl)-1-(4-fluorophenyl)-1H-indole- 6-carboxamide (racemic) | US10947222, Example 49 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H19ClF2N2O3S | ||
| Mol. Mass. | 500.945 | ||
| SMILES | Fc1ccc(cc1)-n1cc(-c2c(F)cccc2Cl)c2ccc(cc12)C(=O)NC1CCS(=O)(=O)C1 |(6.35,-6.37,;5.87,-4.91,;6.9,-3.76,;6.43,-2.3,;4.92,-1.98,;3.89,-3.12,;4.37,-4.59,;4.45,-.51,;5.35,.73,;4.45,1.98,;4.92,3.44,;6.43,3.76,;7.46,2.62,;6.9,5.23,;5.87,6.37,;4.37,6.05,;3.89,4.59,;2.38,4.27,;2.98,1.5,;1.65,2.27,;.31,1.5,;.31,-.04,;1.65,-.81,;2.98,-.04,;-1.02,-.81,;-1.02,-2.35,;-2.35,-.04,;-3.69,-.81,;-3.85,-2.34,;-5.35,-2.66,;-6.12,-1.33,;-7.46,-.56,;-7.46,-2.1,;-5.09,-.18,)| | ||
| Structure | 
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