| Reaction Details |
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 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Ligand | BDBM487701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| IC50 | 13.0±n/a nM |
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| Citation |  Lu, T; Allison, BD; Barbay, JK; Connolly, PJ; Cummings, MD; Diels, G; Edwards, JP; Kreutter, KD; Philippar, U; Shen, F; Thuring, JW; Wu, T; Berthelot, DJ Pyrazole derivatives as MALT1 inhibitors US Patent US10954214 Publication Date 3/23/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
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| Type: | Enzyme |
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| Mol. Mass.: | 92257.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UDY8 |
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| Residue: | 824 |
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| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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| BDBM487701 |
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| n/a |
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| Name | BDBM487701 |
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| Synonyms: | N-(5-chloro-2-methyl-6-(2H- 1,2,3-triazol-2-yl)pyridin-3-yl)- 1-(8-fluoroisoquinolin-4-yl)-5- (trifluoromethyl)-1H-pyrazole-4- carboxamide | US10954214, Compound 123 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H13ClF4N8O |
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| Mol. Mass. | 516.838 |
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| SMILES | Cc1nc(c(Cl)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cncc2c(F)cccc12)-n1nccn1 |
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| Structure | 
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