| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Ligand | BDBM487969 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Assay |
|---|
| IC50 | 7.00±n/a nM |
|---|
| Citation |  Lu, T; Allison, BD; Barbay, JK; Connolly, PJ; Cummings, MD; Diels, G; Edwards, JP; Kreutter, KD; Philippar, U; Shen, F; Thuring, JW; Wu, T; Berthelot, DJ Pyrazole derivatives as MALT1 inhibitors US Patent US10954214 Publication Date 3/23/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92257.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UDY8 |
|---|
| Residue: | 824 |
|---|
| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
|
|
|
|---|
| BDBM487969 |
|---|
| n/a |
|---|
| Name | BDBM487969 |
|---|
| Synonyms: | 4-(4-((5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin-3- yl)carbamoyl)-5- (trifluoromethyl)-1H-pyrazol-1- yl)thieno[2,3-c]pyridine-7- carboxamide | US10954214, Compound 391 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H11ClF3N9O2S |
|---|
| Mol. Mass. | 533.874 |
|---|
| SMILES | NC(=O)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccsc12 |
|---|
| Structure | 
|
|---|
Search and Browse
