Reaction Details |
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Target | Tyrosine-protein kinase JAK1 [866-1154] |
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Ligand | BDBM488667 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | <3.00±n/a nM |
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Citation | Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent US10961228 Publication Date 3/30/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK1 [866-1154] |
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Name: | Tyrosine-protein kinase JAK1 [866-1154] |
Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
Type: | Protein |
Mol. Mass.: | 33185.74 |
Organism: | Homo sapiens (Human) |
Description: | P23458[866-1154] |
Residue: | 289 |
Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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BDBM488667 |
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n/a |
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Name | BDBM488667 |
Synonyms: | (R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophenylamino)- 5-methylpyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide | US10961228, Example 4 |
Type | Small organic molecule |
Emp. Form. | C30H34FN7O3S |
Mol. Mass. | 591.699 |
SMILES | C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(=O)(=O)C2CC2)ncc1C |r| |
Structure |
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