| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Egl nine homolog 1 |
|---|
| Ligand | BDBM301787 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Activity Assay |
|---|
| IC50 | 5800±n/a nM |
|---|
| Citation |  Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent US9598370 Publication Date 3/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Egl nine homolog 1 |
|---|
| Name: | Egl nine homolog 1 |
|---|
| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46035.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9GZT9 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
|
|
|
|---|
| BDBM301787 |
|---|
| n/a |
|---|
| Name | BDBM301787 |
|---|
| Synonyms: | US11426393, Compound Table XV.3 | US9598370, Example 00128 | USRE47437, Example {[5-(4-Cyano-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13N3O4 |
|---|
| Mol. Mass. | 311.2921 |
|---|
| SMILES | COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N |$;;;;;HN;;;;;;;;;;;;;;;;;$| |
|---|
| Structure | 
|
|---|
Search and Browse
