Found 430 hits with Last Name = 'warshakoon' and Initial = 'nc' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198574
((S)-4-(4-chlorophenethyl)-1-(6-((diethylamino)-met...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(Cl)cc2)CC1=O Show InChI InChI=1S/C27H36ClN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | Reactome pathway
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| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192169
((R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1 | Reactome pathway
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192189
(3,4,5-trifluoro-N-(1-(naphthalen-2-ylmethyl)piperi...)Show SMILES Fc1cc(cc(F)c1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H21F3N2O/c24-20-12-18(13-21(25)22(20)26)23(29)27-19-7-9-28(10-8-19)14-15-5-6-16-3-1-2-4-17(16)11-15/h1-6,11-13,19H,7-10,14H2,(H,27,29) | Reactome pathway
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192178
(3,5-dimethoxy-N-((3R)-1-(1-(naphthalen-2-yl)ethyl)...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C25H28N2O3/c1-17(19-9-8-18-6-4-5-7-20(18)12-19)27-11-10-22(16-27)26-25(28)21-13-23(29-2)15-24(14-21)30-3/h4-9,12-15,17,22H,10-11,16H2,1-3H3,(H,26,28)/t17?,22-/m1/s1 | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168507
((E)-N-(1-cinnamylpiperidin-4-yl)-3,5-dimethoxybenz...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(C\C=C\c2ccccc2)CC1 Show InChI InChI=1S/C23H28N2O3/c1-27-21-15-19(16-22(17-21)28-2)23(26)24-20-10-13-25(14-11-20)12-6-9-18-7-4-3-5-8-18/h3-9,15-17,20H,10-14H2,1-2H3,(H,24,26)/b9-6+ | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192174
(4-fluoro-3-methoxy-N-(1-(naphthalen-2-ylmethyl)pip...)Show SMILES COc1cc(ccc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H25FN2O2/c1-29-23-15-20(8-9-22(23)25)24(28)26-21-10-12-27(13-11-21)16-17-6-7-18-4-2-3-5-19(18)14-17/h2-9,14-15,21H,10-13,16H2,1H3,(H,26,28) | Reactome pathway
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198573
((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2ccc(F)cc2)CC1=O Show InChI InChI=1S/C27H36FN3O/c1-3-29(4-2)19-22-5-8-24-18-26(12-9-23(24)17-22)31-16-15-30(20-27(31)32)14-13-21-6-10-25(28)11-7-21/h5-8,10-11,17,26H,3-4,9,12-16,18-20H2,1-2H3/t26-/m0/s1 | Reactome pathway
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of binding to MCH-R1 |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192163
((R,E)-N-(1-cinnamylpyrrolidin-3-yl)-3,5-dimethoxyb...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C\C=C\c2ccccc2)C1 Show InChI InChI=1S/C22H26N2O3/c1-26-20-13-18(14-21(15-20)27-2)22(25)23-19-10-12-24(16-19)11-6-9-17-7-4-3-5-8-17/h3-9,13-15,19H,10-12,16H2,1-2H3,(H,23,25)/b9-6+/t19-/m1/s1 | Reactome pathway
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192161
(3,4-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1ccc(cc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-21-8-7-19(14-22(21)25)23(28)26-20-9-11-27(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H,26,28) | Reactome pathway
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192162
(3,5-dimethoxy-N-((3R)-1-((E)-4-phenylbut-3-en-2-yl...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)\C=C\c1ccccc1 Show InChI InChI=1S/C23H28N2O3/c1-17(9-10-18-7-5-4-6-8-18)25-12-11-20(16-25)24-23(26)19-13-21(27-2)15-22(14-19)28-3/h4-10,13-15,17,20H,11-12,16H2,1-3H3,(H,24,26)/b10-9+/t17?,20-/m1/s1 | Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192160
(3,5-dimethoxy-N-(1-(1-(naphthalen-2-yl)ethyl)piper...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H30N2O3/c1-18(20-9-8-19-6-4-5-7-21(19)14-20)28-12-10-23(11-13-28)27-26(29)22-15-24(30-2)17-25(16-22)31-3/h4-9,14-18,23H,10-13H2,1-3H3,(H,27,29) | Reactome pathway
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192177
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-8,13-16,22H,9-12,17H2,1-2H3,(H,26,28) | Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192165
(3-methoxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-...)Show SMILES COc1cccc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H26N2O2/c1-28-23-8-4-7-21(16-23)24(27)25-22-11-13-26(14-12-22)17-18-9-10-19-5-2-3-6-20(19)15-18/h2-10,15-16,22H,11-14,17H2,1H3,(H,25,27) | Reactome pathway
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191756
(4'-fluoro-biphenyl-4-carboxylic acid methyl-(3-pip...)Show SMILES CN(Cc1cccc2cc(CN3CCCCC3)cnc12)C(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C30H30FN3O/c1-33(30(35)25-10-8-23(9-11-25)24-12-14-28(31)15-13-24)21-27-7-5-6-26-18-22(19-32-29(26)27)20-34-16-3-2-4-17-34/h5-15,18-19H,2-4,16-17,20-21H2,1H3 | Reactome pathway
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| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192182
(CHEMBL214778 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 Show InChI InChI=1S/C25H27FN2O3/c1-30-23-13-20(14-24(15-23)31-2)25(29)27-22-7-9-28(10-8-22)16-17-3-4-19-12-21(26)6-5-18(19)11-17/h3-6,11-15,22H,7-10,16H2,1-2H3,(H,27,29) | Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198582
((S)-4-(2-cyclohexylethyl)-1-(6-((diethylamino)meth...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCC2CCCCC2)CC1=O Show InChI InChI=1S/C27H43N3O/c1-3-28(4-2)20-23-10-11-25-19-26(13-12-24(25)18-23)30-17-16-29(21-27(30)31)15-14-22-8-6-5-7-9-22/h10-11,18,22,26H,3-9,12-17,19-21H2,1-2H3/t26-/m0/s1 | Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192157
(4-fluoro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27) | Reactome pathway
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192173
((1R,5S,6r)-N-(3,4-difluorobenzyl)-3-(naphthalen-2-...)Show SMILES Fc1ccc(CNC(=O)[C@@H]2[C@H]3CN(Cc4ccc5ccccc5c4)C[C@@H]23)cc1F Show InChI InChI=1S/C24H22F2N2O/c25-21-8-6-15(10-22(21)26)11-27-24(29)23-19-13-28(14-20(19)23)12-16-5-7-17-3-1-2-4-18(17)9-16/h1-10,19-20,23H,11-14H2,(H,27,29)/t19-,20+,23+ | Reactome pathway
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198575
(1-((S)-6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCC2CCCS2)CC1=O Show InChI InChI=1S/C25H39N3OS/c1-3-26(4-2)18-20-7-8-22-17-23(10-9-21(22)16-20)28-14-13-27(19-25(28)29)12-11-24-6-5-15-30-24/h7-8,16,23-24H,3-6,9-15,17-19H2,1-2H3/t23-,24?/m0/s1 | Reactome pathway
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| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191752
(6-(4-chlorophenyl)-3-((3-((4-hydroxypiperidin-1-yl...)Show SMILES OC1CCN(Cc2cnc3c(Cn4cnc5cc(sc5c4=O)-c4ccc(Cl)cc4)cccc3c2)CC1 Show InChI InChI=1S/C28H25ClN4O2S/c29-22-6-4-19(5-7-22)25-13-24-27(36-25)28(35)33(17-31-24)16-21-3-1-2-20-12-18(14-30-26(20)21)15-32-10-8-23(34)9-11-32/h1-7,12-14,17,23,34H,8-11,15-16H2 | Reactome pathway
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PubMed
| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192183
(3,5-diethoxy-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES CCOc1cc(OCC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C27H32N2O3/c1-3-31-25-16-23(17-26(18-25)32-4-2)27(30)28-24-11-13-29(14-12-24)19-20-9-10-21-7-5-6-8-22(21)15-20/h5-10,15-18,24H,3-4,11-14,19H2,1-2H3,(H,28,30) | Reactome pathway
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| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192168
((R)-4-fluoro-3-methoxy-N-(1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(ccc1F)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C23H23FN2O2/c1-28-22-13-19(8-9-21(22)24)23(27)25-20-10-11-26(15-20)14-16-6-7-17-4-2-3-5-18(17)12-16/h2-9,12-13,20H,10-11,14-15H2,1H3,(H,25,27)/t20-/m1/s1 | Reactome pathway
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| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192195
(3,5-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1cc(F)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-20-12-19(13-21(25)14-20)23(28)26-22-7-9-27(10-8-22)15-16-5-6-17-3-1-2-4-18(17)11-16/h1-6,11-14,22H,7-10,15H2,(H,26,28) | Reactome pathway
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| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192192
((R)-3-methoxy-N-(1-(naphthalen-2-ylmethyl)pyrrolid...)Show SMILES COc1cccc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C23H24N2O2/c1-27-22-8-4-7-20(14-22)23(26)24-21-11-12-25(16-21)15-17-9-10-18-5-2-3-6-19(18)13-17/h2-10,13-14,21H,11-12,15-16H2,1H3,(H,24,26)/t21-/m1/s1 | Reactome pathway
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| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192164
(3,5-dimethoxy-N-(4-methyl-1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1(C)CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O3/c1-26(27-25(29)22-15-23(30-2)17-24(16-22)31-3)10-12-28(13-11-26)18-19-8-9-20-6-4-5-7-21(20)14-19/h4-9,14-17H,10-13,18H2,1-3H3,(H,27,29) | Reactome pathway
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| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191768
(6-(4-chlorophenyl)-3-((3-(pyrrolidin-1-ylmethyl)qu...)Show SMILES Clc1ccc(cc1)-c1cc2ncn(Cc3cccc4cc(CN5CCCC5)cnc34)c(=O)c2s1 Show InChI InChI=1S/C27H23ClN4OS/c28-22-8-6-19(7-9-22)24-13-23-26(34-24)27(33)32(17-30-23)16-21-5-3-4-20-12-18(14-29-25(20)21)15-31-10-1-2-11-31/h3-9,12-14,17H,1-2,10-11,15-16H2 | Reactome pathway
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| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50198577
((S)-1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydro...)Show SMILES CCN(CC)Cc1ccc2C[C@H](CCc2c1)N1CCN(CCc2cccc(c2)C(F)(F)F)CC1=O Show InChI InChI=1S/C28H36F3N3O/c1-3-32(4-2)19-22-8-9-24-18-26(11-10-23(24)16-22)34-15-14-33(20-27(34)35)13-12-21-6-5-7-25(17-21)28(29,30)31/h5-9,16-17,26H,3-4,10-15,18-20H2,1-2H3/t26-/m0/s1 | Reactome pathway
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| 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Functional antagonism of MCH-R1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 819-22 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.052
BindingDB Entry DOI: 10.7270/Q2736QKD |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50241090
(3,5-dimethoxy-N-(1-((6-methoxynaphthalen-2-yl)meth...)Show SMILES COc1ccc2cc(CN3CCC(CC3)NC(=O)c3cc(OC)cc(OC)c3)ccc2c1 Show InChI InChI=1S/C26H30N2O4/c1-30-23-7-6-19-12-18(4-5-20(19)13-23)17-28-10-8-22(9-11-28)27-26(29)21-14-24(31-2)16-25(15-21)32-3/h4-7,12-16,22H,8-11,17H2,1-3H3,(H,27,29) | Reactome pathway
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| 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191765
(4'-fluoro-biphenyl-4-carboxylic acid (3-diethylami...)Show SMILES CCN(CC)Cc1cnc2c(CNC(=O)c3ccc(cc3)-c3ccc(F)cc3)cccc2c1 Show InChI InChI=1S/C28H28FN3O/c1-3-32(4-2)19-20-16-24-6-5-7-25(27(24)30-17-20)18-31-28(33)23-10-8-21(9-11-23)22-12-14-26(29)15-13-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33) | Reactome pathway
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| 102 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191753
(6-(4-chlorophenyl)-3-((3-((4-methylpiperazin-1-yl)...)Show SMILES CN1CCN(Cc2cnc3c(Cn4cnc5cc(sc5c4=O)-c4ccc(Cl)cc4)cccc3c2)CC1 Show InChI InChI=1S/C28H26ClN5OS/c1-32-9-11-33(12-10-32)16-19-13-21-3-2-4-22(26(21)30-15-19)17-34-18-31-24-14-25(36-27(24)28(34)35)20-5-7-23(29)8-6-20/h2-8,13-15,18H,9-12,16-17H2,1H3 | Reactome pathway
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| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192167
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27) | Reactome pathway
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| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192184
(3-(dimethylamino)-N-(1-(naphthalen-2-ylmethyl)pipe...)Show SMILES CN(C)c1cccc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H29N3O/c1-27(2)24-9-5-8-22(17-24)25(29)26-23-12-14-28(15-13-23)18-19-10-11-20-6-3-4-7-21(20)16-19/h3-11,16-17,23H,12-15,18H2,1-2H3,(H,26,29) | Reactome pathway
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| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191766
(6-(4-chlorophenyl)-3-((3-((diethylamino)methyl)qui...)Show SMILES CCN(CC)Cc1cnc2c(Cn3cnc4cc(sc4c3=O)-c3ccc(Cl)cc3)cccc2c1 Show InChI InChI=1S/C27H25ClN4OS/c1-3-31(4-2)15-18-12-20-6-5-7-21(25(20)29-14-18)16-32-17-30-23-13-24(34-26(23)27(32)33)19-8-10-22(28)11-9-19/h5-14,17H,3-4,15-16H2,1-2H3 | Reactome pathway
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192187
(3,5-dimethoxy-N-((3R,4R)-3-methyl-1-(naphthalen-2-...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C[C@H]1C Show InChI InChI=1S/C26H30N2O3/c1-18-16-28(17-19-8-9-20-6-4-5-7-21(20)12-19)11-10-25(18)27-26(29)22-13-23(30-2)15-24(14-22)31-3/h4-9,12-15,18,25H,10-11,16-17H2,1-3H3,(H,27,29)/t18-,25-/m1/s1 | Reactome pathway
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| 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191755
(2-(((8-((6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyri...)Show SMILES CN(CC(=O)N(C)C)Cc1cnc2c(Cn3cnc4cc(sc4c3=O)-c3ccc(Cl)cc3)cccc2c1 Show InChI InChI=1S/C28H26ClN5O2S/c1-32(2)25(35)16-33(3)14-18-11-20-5-4-6-21(26(20)30-13-18)15-34-17-31-23-12-24(37-27(23)28(34)36)19-7-9-22(29)10-8-19/h4-13,17H,14-16H2,1-3H3 | Reactome pathway
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| 136 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192191
(3,5-dimethoxy-N-(1-((1,2,3,4-tetrahydronaphthalen-...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC2CCc3ccccc3C2)CC1 Show InChI InChI=1S/C25H32N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-6,14-16,18,22H,7-13,17H2,1-2H3,(H,26,28) | Reactome pathway
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| 136 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191764
(4'-fluoro-biphenyl-4-carboxylic acid [3-((S)-3-hyd...)Show SMILES O[C@H]1CCN(Cc2cnc3c(CNC(=O)c4ccc(cc4)-c4ccc(F)cc4)cccc3c2)C1 Show InChI InChI=1S/C28H26FN3O2/c29-25-10-8-21(9-11-25)20-4-6-22(7-5-20)28(34)31-16-24-3-1-2-23-14-19(15-30-27(23)24)17-32-13-12-26(33)18-32/h1-11,14-15,26,33H,12-13,16-18H2,(H,31,34)/t26-/m0/s1 | Reactome pathway
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| 142 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192170
(3,5-dimethoxy-N-(1-((1-methyl-1H-indol-2-yl)methyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2cc3ccccc3n2C)CC1 Show InChI InChI=1S/C24H29N3O3/c1-26-20(12-17-6-4-5-7-23(17)26)16-27-10-8-19(9-11-27)25-24(28)18-13-21(29-2)15-22(14-18)30-3/h4-7,12-15,19H,8-11,16H2,1-3H3,(H,25,28) | Reactome pathway
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| 142 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192193
(3,5-dimethoxy-N-methyl-N-(1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)N(C)C1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O3/c1-27(26(29)22-15-24(30-2)17-25(16-22)31-3)23-10-12-28(13-11-23)18-19-8-9-20-6-4-5-7-21(20)14-19/h4-9,14-17,23H,10-13,18H2,1-3H3 | Reactome pathway
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| 169 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192186
(3,5-dimethoxy-N-((3S,4R)-3-methyl-1-(naphthalen-2-...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C[C@@H]1C Show InChI InChI=1S/C26H30N2O3/c1-18-16-28(17-19-8-9-20-6-4-5-7-21(20)12-19)11-10-25(18)27-26(29)22-13-23(30-2)15-24(14-22)31-3/h4-9,12-15,18,25H,10-11,16-17H2,1-3H3,(H,27,29)/t18-,25+/m0/s1 | Reactome pathway
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| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191761
(4'-fluoro-biphenyl-4-carboxylic acid [3-(4-hydroxy...)Show SMILES OC1CCN(Cc2cnc3c(CNC(=O)c4ccc(cc4)-c4ccc(F)cc4)cccc3c2)CC1 Show InChI InChI=1S/C29H28FN3O2/c30-26-10-8-22(9-11-26)21-4-6-23(7-5-21)29(35)32-18-25-3-1-2-24-16-20(17-31-28(24)25)19-33-14-12-27(34)13-15-33/h1-11,16-17,27,34H,12-15,18-19H2,(H,32,35) | Reactome pathway
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| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191762
(6-(4-chlorophenyl)-3-((3-((dimethylamino)methyl)qu...)Show SMILES CN(C)Cc1cnc2c(Cn3cnc4cc(sc4c3=O)-c3ccc(Cl)cc3)cccc2c1 Show InChI InChI=1S/C25H21ClN4OS/c1-29(2)13-16-10-18-4-3-5-19(23(18)27-12-16)14-30-15-28-21-11-22(32-24(21)25(30)31)17-6-8-20(26)9-7-17/h3-12,15H,13-14H2,1-2H3 | Reactome pathway
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| 197 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192159
(CHEMBL385535 | N-(1-(3,4-dichlorobenzyl)piperidin-...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 Show InChI InChI=1S/C21H24Cl2N2O3/c1-27-17-10-15(11-18(12-17)28-2)21(26)24-16-5-7-25(8-6-16)13-14-3-4-19(22)20(23)9-14/h3-4,9-12,16H,5-8,13H2,1-2H3,(H,24,26) | Reactome pathway
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| 205 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192188
(4-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc(cc1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H23ClN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27) | Reactome pathway
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| 232 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192166
(3,4,5-trimethoxy-N-(1-(naphthalen-2-ylmethyl)piper...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O4/c1-30-23-15-21(16-24(31-2)25(23)32-3)26(29)27-22-10-12-28(13-11-22)17-18-8-9-19-6-4-5-7-20(19)14-18/h4-9,14-16,22H,10-13,17H2,1-3H3,(H,27,29) | Reactome pathway
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| 286 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192158
(CHEMBL214684 | N-(1-benzylpiperidin-4-yl)-3,5-dime...)Show InChI InChI=1S/C21H26N2O3/c1-25-19-12-17(13-20(14-19)26-2)21(24)22-18-8-10-23(11-9-18)15-16-6-4-3-5-7-16/h3-7,12-14,18H,8-11,15H2,1-2H3,(H,22,24) | Reactome pathway
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| 302 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191767
(4'-fluoro-biphenyl-4-carboxylic acid [3-(4-methane...)Show SMILES CS(=O)(=O)C1CCN(Cc2cnc3c(CNC(=O)c4ccc(cc4)-c4ccc(F)cc4)cccc3c2)CC1 Show InChI InChI=1S/C30H30FN3O3S/c1-38(36,37)28-13-15-34(16-14-28)20-21-17-25-3-2-4-26(29(25)32-18-21)19-33-30(35)24-7-5-22(6-8-24)23-9-11-27(31)12-10-23/h2-12,17-18,28H,13-16,19-20H2,1H3,(H,33,35) | Reactome pathway
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| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191754
(CHEMBL213817 | N-(3-diethylaminomethyl-quinolin-8-...)Show SMILES CCN(CC)Cc1cnc2c(CNC(=O)c3ccc(nc3)-c3ccc(F)cc3)cccc2c1 Show InChI InChI=1S/C27H27FN4O/c1-3-32(4-2)18-19-14-21-6-5-7-22(26(21)30-15-19)16-31-27(33)23-10-13-25(29-17-23)20-8-11-24(28)12-9-20/h5-15,17H,3-4,16,18H2,1-2H3,(H,31,33) | Reactome pathway
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| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192179
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26) | Reactome pathway
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| 347 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50191760
(CHEMBL216038 | N-(3-dimethylaminomethyl-quinolin-8...)Show SMILES CN(C)Cc1cnc2c(CNC(=O)c3ccc(nc3)-c3ccc(F)cc3)cccc2c1 Show InChI InChI=1S/C25H23FN4O/c1-30(2)16-17-12-19-4-3-5-20(24(19)28-13-17)14-29-25(31)21-8-11-23(27-15-21)18-6-9-22(26)10-7-18/h3-13,15H,14,16H2,1-2H3,(H,29,31) | Reactome pathway
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| 414 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to MCHR1 by radioligand binding assay |
Bioorg Med Chem Lett 16: 5207-11 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.006
BindingDB Entry DOI: 10.7270/Q2SX6CV3 |
More data for this
Ligand-Target Pair | |
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