| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM504173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Transcreener-Fluorecescence Polarization Assay |
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| Ki | 2.30±n/a nM |
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| Citation |  Bryan, MC; Do, S; Drobnick, J; Gobbi, A; Katsumoto, T; Kiefer, Jr., JR; Liang, J; Rajapaksa, NS; Chen, Y; Fu, L; Lai, KW; Liu, Z; Wai, J; Wang, F Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators US Patent US11034698 Publication Date 6/15/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM504173 |
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| n/a |
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| Name | BDBM504173 |
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| Synonyms: | N-(6-(4-((4-Chloro-1H- imidazol-5-yl)methyl)piperazin- 1-yl)-2,2-dimethyl-2,3- dihydrobenzofuran-5- yl)pyrazolo[1,5-a)pyrimidine-3 carboxamide | US11034698, Example 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClN8O2 |
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| Mol. Mass. | 506.987 |
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| SMILES | CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2O1)N1CCN(Cc2[nH]cnc2Cl)CC1 |
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| Structure | 
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