| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
|---|
| Ligand | BDBM517376 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| IC50 | 23.0±n/a nM |
|---|
| Citation |  Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US11104690 Publication Date 8/31/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 2 |
|---|
| Name: | Diacylglycerol O-acyltransferase 2 |
|---|
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 43848.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96PD7 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
|---|
| BDBM517376 |
|---|
| n/a |
|---|
| Name | BDBM517376 |
|---|
| Synonyms: | 3-(2-chlorophenyl)-1-(5- chloropyridin-2-yl)-N-(1,1- dioxidotetrahydrothiophen-3-yl)-1H- indazole-6-carboxamide (enantiomer A) | US11104690, Example 173-A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H18Cl2N4O3S |
|---|
| Mol. Mass. | 501.385 |
|---|
| SMILES | Clc1ccc(nc1)-n1nc(-c2ccccc2Cl)c2ccc(cc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
