| Reaction Details |
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 | Report a problem with these data |
| Target | Metallo-beta-lactamase VIM-2 |
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| Ligand | BDBM531041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity: Determination of IC50 |
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| IC50 | 114±n/a nM |
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| Citation |  Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent US11207312 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metallo-beta-lactamase VIM-2 |
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| Name: | Metallo-beta-lactamase VIM-2 |
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| Synonyms: | Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2) |
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| Type: | Protein |
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| Mol. Mass.: | 28318.00 |
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| Organism: | Pseudomonas aeruginosa (g-Proteobacteria) |
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| Description: | n/a |
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| Residue: | 266 |
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| Sequence: | MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQ
SFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRV
GGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHS
TDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGH
GLPGGLDLLKHTTNVVKAHTNRSVVE
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| BDBM531041 |
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| n/a |
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| Name | BDBM531041 |
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| Synonyms: | (R)-N1-(3-amino-2- hydroxypropyl)-4-(4-(2- hydroxyethyl)-3,3- dimethylpiperazin-1-yl)-3- (2H-tetrazol-5-yl)benzene-1,2- disulfonamide | US11207312, Example 173 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H31N9O6S2 |
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| Mol. Mass. | 533.625 |
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| SMILES | CC1(C)CN(CCN1CCO)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN |r| |
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| Structure | 
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