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TargetBcl-2-like protein 1 [1-212]
LigandBDBM544484
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50>20000±n/a nM
Citation Ferrara, SJSerrano-Wu, MHLemke, CMcKinney, DFitzgerald, MNasveschuk, CLazarski, KFurst, LWei, GMcCarren, PRThede, KMengel, AChrist, CKuhnke, JJohannes, SABuchgraber, PKlar, USack, UKaulfuss, SFernandez-Montalvan, AEWerbeck, NMönning, U Macrocyclic fluorine substituted indole derivatives US Patent US11286263 Publication Date 3/29/2022
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1 [1-212]
Name:Bcl-2-like protein 1 [1-212]
Synonyms:B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX
Type:Protein
Mol. Mass.:23772.86
Organism:Homo sapiens (Human)
Description:Q07817[1-212]
Residue:212
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM544484
n/a
NameBDBM544484
Synonyms:(rac)-1-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-13-fluoro-11,12-dimethyl-4,5,6,7,9,11-hexahydropyrazolo[4′,3′:9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid | US11286263, Example 20
TypeSmall organic molecule
Emp. Form.C30H33ClFN3O4
Mol. Mass.554.052
SMILESCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cc(C)c(Cl)c(C)c4)c4ccc(F)c-2c34)nn1C
Structure
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