| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bcl-2-like protein 1 [1-212] |
|---|
| Ligand | BDBM544513 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Ferrara, SJ; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Furst, L; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Sack, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U Macrocyclic fluorine substituted indole derivatives US Patent US11286263 Publication Date 3/29/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bcl-2-like protein 1 [1-212] |
|---|
| Name: | Bcl-2-like protein 1 [1-212] |
|---|
| Synonyms: | B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 23772.86 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07817[1-212] |
|---|
| Residue: | 212 |
|---|
| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNR
|
|
|
|---|
| BDBM544513 |
|---|
| n/a |
|---|
| Name | BDBM544513 |
|---|
| Synonyms: | 8-carboxy-4-fluoro-2,3,14,14-tetramethyl-7-[3-(1-naphthyloxy)propyl]-10,11,12,13,14,15-hexa-hydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indol-14-ium trifluroacetate | US11286263, Example 50 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H38FN4O3 |
|---|
| Mol. Mass. | 569.6884 |
|---|
| SMILES | Cc1c-2c(C[N+](C)(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(F)c-2c34)nn1C |
|---|
| Structure | 
|
|---|
Search and Browse
