Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Estrogen receptor |
---|
Ligand | BDBM306734 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | MCF-7 ER Down-Regulation Assay |
---|
IC50 | 0.140±n/a nM |
---|
Citation | Scott, JS; Moss, TA; O Donovan, DH; Nissink, JW; Hughes, SJ; Barlaam, BC; Broo, DA; Yang, B; Varnes, JG; Wu, D Chemical compounds US Patent US10149839 Publication Date 12/11/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Estrogen receptor |
---|
Name: | Estrogen receptor |
Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
Type: | Protein |
Mol. Mass.: | 66230.44 |
Organism: | Homo sapiens (Human) |
Description: | P03372 |
Residue: | 595 |
Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
BDBM306734 |
---|
n/a |
---|
Name | BDBM306734 |
Synonyms: | 3-(3,5- difluoro-4- ((1R,3R)-2-(2- fluoro-2-methyl- propyl)-3- methyl-2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)phenoxy)-2- ((3-fluoro- propyl)amino) propan-1-ol | BDBM306766 | BDBM306767 | US10149839, Example 20 |
Type | Small organic molecule |
Emp. Form. | C28H35F4N3O2 |
Mol. Mass. | 521.59 |
SMILES | C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCC(CO)NCCCF)cc1F |r| |
Structure |
|