Reaction Details |
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Target | Activin receptor type-1B |
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Ligand | BDBM603696 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity |
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IC50 | 4206±n/a nM |
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Citation | Yu, PB; Huang, W; Sanderson, PE; Jiang, J; Shamim, K; Zheng, W; Huang, X; Tawa, G; Lee, A; Alimardanov, A; Huang, J ALK2 inhibitors and methods for inhibiting BMP signaling US Patent US11654147 Publication Date 5/23/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1B |
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Name: | Activin receptor type-1B |
Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
Type: | PROTEIN |
Mol. Mass.: | 56810.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_587064 |
Residue: | 505 |
Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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BDBM603696 |
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n/a |
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Name | BDBM603696 |
Synonyms: | US11654147, Compound 15 | US11654147, Compound 346 | US11654147, Compound 351 | US11654147, Compound 45 |
Type | Small organic molecule |
Emp. Form. | C26H30FN7O |
Mol. Mass. | 475.5611 |
SMILES | COc1cc2c(ccnc2cc1F)-c1cnn2cc(cnc12)N1CCC(CC1)N1CCN(C)CC1 |
Structure |
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