| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
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| Ligand | BDBM604246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay for MASP-2 |
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| Ki | <500±n/a nM |
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| Citation |  Cutshall, NS; Gage, JL; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Little, TL; Metz, M; Nollert Von Specht, PK; Price, LM; Tsoung, J MASP-2 inhibitors and methods of use US Patent US11661418 Publication Date 5/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 2 |
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| Name: | Mannan-binding lectin serine protease 2 |
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| Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75689.43 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117891 |
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| Residue: | 686 |
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| Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
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| BDBM604246 |
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| n/a |
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| Name | BDBM604246 |
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| Synonyms: | Preparation of (S)—N-(4-carbamimidoylbenzyl)-1-((2R,4S)-1-methyl-4-phenylpiperidine-2-carbonyl)azetidine-2-carboxamide di-trifluoroacetate SALT | US11661418, Compound I-17 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N5O2 |
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| Mol. Mass. | 433.5459 |
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| SMILES | CN1CC[C@@H](C[C@@H]1C(=O)N1CC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N)c1ccccc1 |r| |
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| Structure | 
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