| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Ligand | BDBM606103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Selectivity Kinase Assay |
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| Ki | 6.10±n/a nM |
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| Citation |  Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent US11684616 Publication Date 6/27/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91316.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586597 |
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| Residue: | 833 |
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| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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| BDBM606103 |
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| n/a |
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| Name | BDBM606103 |
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| Synonyms: | US11684616, Example 6a | US11684616, Example 6b |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N7O2 |
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| Mol. Mass. | 459.5435 |
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| SMILES | COC[C@@H](N)c1nc(cc2C(=O)N(Cc12)c1cccc(n1)-c1nnc2CC[C@H](C)n12)C1(C)CC1 |r| |
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| Structure | 
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