| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Ligand | BDBM606200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Selectivity Kinase Assay |
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| Ki | 0.120±n/a nM |
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| Citation |  Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent US11684616 Publication Date 6/27/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
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| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91316.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586597 |
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| Residue: | 833 |
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| Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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| BDBM606200 |
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| n/a |
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| Name | BDBM606200 |
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| Synonyms: | 6-(dimethyl- amino)- 2-{6-[(5S)-5- ethyl-6,7- dihydro-5H- pyrrolo[2,1-c] [1,2,4]triazol-3- yl]pyridin-2-yl}- 4-[(methyl- amino)methyl]- 2,3-dihydro-1H- pyrrolo[3,4-c] pyridin-1-one alpha = +70.7$#176; | US11684616, Example 206 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N8O |
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| Mol. Mass. | 432.5214 |
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| SMILES | CC[C@H]1CCc2nnc(-c3cccc(n3)N3Cc4c(cc(nc4CNC)N(C)C)C3=O)n12 |r| |
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| Structure | 
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