Ki Summary

Reaction Details

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Target

GTPase KRas [G12C]

Ligand

BDBM608933

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay (SPA)

IC50

>5000±n/a nM

Citation

Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12C]

Name:

GTPase KRas [G12C]

Synonyms:

GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21702.19

Organism:

Homo sapiens (Human)

Description:

P01116[G12C]

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM608933

n/a

Name

BDBM608933

Synonyms:

US11702409, Example 39a | US11702409, Example 39b

Type

Small organic molecule

Emp. Form.

C31H34ClN5O3

Mol. Mass.

560.086

SMILES

COCCOCc1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12 |(7.2,.03,;8.69,-.37,;9.09,-1.86,;8,-2.95,;6.51,-2.55,;5.42,-3.64,;3.94,-3.24,;2.79,-4.27,;1.33,-3.79,;1.01,-2.29,;2.15,-1.26,;3.61,-1.73,;-.46,-1.81,;-.93,-.35,;-2.47,-.35,;-3.24,.99,;-4.73,1.39,;-4.33,2.87,;-2.85,2.48,;-5.82,3.27,;-5.42,4.76,;-3.94,4.36,;-6.51,5.85,;-6.11,7.34,;-8,5.45,;-9.09,6.54,;-2.95,-1.81,;-4.42,-2.29,;-1.7,-2.72,;-1.7,-4.26,;-3.04,-5.03,;-4.37,-4.26,;-3.04,-6.57,;-4.37,-7.34,;-1.7,-7.34,;-.37,-6.57,;1.09,-7.04,;2,-5.8,;1.09,-4.55,;-.37,-5.03,)|

Structure