| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin reductase 2 |
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| Ligand | BDBM616849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PTGR2 Inhibiting Activity Assay |
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| IC50 | 23.5±n/a nM |
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| Citation |  Tsou, LK; Hung, M; Chen, CW; Hsieh, M; Chang, Y; Chuang, LM PTGR2 INHIBITORS AND THEIR USE US Patent US20230279008 Publication Date 9/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin reductase 2 |
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| Name: | Prostaglandin reductase 2 |
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| Synonyms: | 15-oxoprostaglandin 13-reductase | PRG-2 | Zinc-binding alcohol dehydrogenase domain-containing protein 1 |
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| Type: | Protein |
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| Mol. Mass.: | 38492.48 |
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| Organism: | Human |
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| Description: | Q8N8N7 |
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| Residue: | 351 |
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| Sequence: | MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDT
GTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQ
LVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGC
SRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTV
ISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGI
LQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
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| BDBM616849 |
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| n/a |
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| Name | BDBM616849 |
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| Synonyms: | 6-(3-chlorobenzyl)-5-methyl-2-((4-(thiazol-2-yl)piperazin-1-yl)methyl)-[1,2,4]triazolo[1,5-a] pyrimidin-7(3H)-one | US20230279008, Compound 26 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22ClN7OS |
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| Mol. Mass. | 455.964 |
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| SMILES | Cc1[nH]c2nc(CN3CCN(CC3)c3nccs3)nn2c(=O)c1Cc1cccc(Cl)c1 |
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| Structure | 
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