| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
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| Ligand | BDBM646460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzymatic Activity Assay on WRN Helicase |
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| IC50 | 40.0±n/a nM |
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| Citation |  Bordas, V; Brun, J; Furegati, M; Hamon, J; Hinrichs, JH; Holzer, P; Limam, F; Möbitz, H; Nocito, S; Plattner, S; Schmiedeberg, N; Schoepfer, J; Strang, RS; Zecri, F Bicyclic compounds and their uses US Patent US11878973 Publication Date 1/23/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
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| Name: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238] |
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| Synonyms: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (517-1238) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 81717.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14191[517-1238] |
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| Residue: | 722 |
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| Sequence: | NEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYG
KSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKY
RIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPM
VPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVK
TSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQ
CVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLN
RHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCC
DNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLAD
QYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANT
ESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCD
KISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPA
ILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSST
KP
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| BDBM646460 |
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| n/a |
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| Name | BDBM646460 |
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| Synonyms: | US11878973, Example 51 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31ClF5N9O5S |
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| Mol. Mass. | 760.134 |
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| SMILES | CCc1c(N2CCN(CC2)C(=O)c2ncnc(C)c2O)c(=O)n2nc(nc2n1CC(=O)Nc1ccc(cc1Cl)S(F)(F)(F)(F)F)C1=CCOCC1 |t:50| |
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| Structure | 
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