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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Ligand | BDBM647687 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | RIPK1-ADP-Glo Enzymatic Assay | ||
| EC50 | 152±n/a nM | ||
| Citation |  Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 1 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 75926.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13546 | ||
| Residue: | 671 | ||
| Sequence: |
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| BDBM647687 | |||
| n/a | |||
| Name | BDBM647687 | ||
| Synonyms: | (5S)-5-(3,5-difluorophenyl)-2-(1- methyl-2-oxabicyclo[2.1.1]hexan-4- yl)-2,5,6,7-tetrahydro-3H-pyrrolo[2,1- c][1,2,4]triazol-3-one | US20240025912, Compound 1-14 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H17F2N3O2 | ||
| Mol. Mass. | 333.3326 | ||
| SMILES | CC12CC(C1)(CO2)n1nc2CC[C@@H](c3cc(F)cc(F)c3)n2c1=O |r,wU:12.14,(6.48,-.93,;5.23,-1.84,;3.77,-1.36,;2.86,-2.61,;4.4,-2.61,;3.77,-3.86,;5.23,-3.38,;1.32,-2.61,;.42,-3.86,;-1.05,-3.38,;-2.51,-3.86,;-3.42,-2.61,;-2.51,-1.36,;-2.99,.1,;-1.96,1.25,;-2.43,2.71,;-1.4,3.86,;-3.94,3.03,;-4.97,1.89,;-6.48,2.21,;-4.5,.42,;-1.05,-1.84,;.42,-1.36,;.89,.1,)| | ||
| Structure | 
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