| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK3 [811-1124] |
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| Ligand | BDBM264181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Studies |
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| IC50 | >30000±n/a nM |
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| Citation |  Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK3 [811-1124] |
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| Name: | Tyrosine-protein kinase JAK3 [811-1124] |
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| Synonyms: | JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124) |
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| Type: | Protein |
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| Mol. Mass.: | 35601.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52333[811-1124] |
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| Residue: | 314 |
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| Sequence: | CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQR
EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYS
SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP
IFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRL
LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAF
TAHPEGKHHSLSFS
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| BDBM264181 |
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| n/a |
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| Name | BDBM264181 |
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| Synonyms: | (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide | US10167276, Example 5 | US10654835, Example 5 | US11247983, Example 5 | US9714236, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32FN9O2 |
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| Mol. Mass. | 521.5898 |
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| SMILES | COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12 |r| |
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| Structure | 
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