Reaction Details |
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Target | Tyrosine-protein kinase JAK2 [808-1132] |
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Ligand | BDBM264217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Studies |
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IC50 | 1580±n/a nM |
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Citation | Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK2 [808-1132] |
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Name: | Tyrosine-protein kinase JAK2 [808-1132] |
Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
Type: | Protein |
Mol. Mass.: | 39171.39 |
Organism: | Homo sapiens (Human) |
Description: | O60674[808-1132] |
Residue: | 335 |
Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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BDBM264217 |
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n/a |
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Name | BDBM264217 |
Synonyms: | (2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4- yl}-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide | US10167276, Example 37 | US10654835, Example 37 | US11247983, Example 37 | US9714236, 37 |
Type | Small organic molecule |
Emp. Form. | C25H30BrN9O2 |
Mol. Mass. | 568.469 |
SMILES | COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12 |r| |
Structure |
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