| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM319617 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | 5-HT1A Receptor Agonism Activity Test |
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| EC50 | 1.05±n/a nM |
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| Citation |  Jiang, H; Wang, Z; Li, J; Zhang, R; He, Y; Liu, Y; Bi, M; Liu, Z; Tian, G; Chen, W; Yang, F; Wu, C; Wang, Y; Jiang, X; Yin, J; Wang, G; Shen, J Heterocyclic compounds, process for preparation of the same and use thereof US Patent US10174011 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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|
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| BDBM319617 |
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| n/a |
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| Name | BDBM319617 |
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| Synonyms: | 5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one | US10174011, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClN3OS |
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| Mol. Mass. | 411.948 |
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| SMILES | Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1cccc2sccc12 |
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| Structure | 
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