Reaction Details |
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Target | High affinity nerve growth factor receptor [441-796] |
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Ligand | BDBM136654 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ELISA Assay |
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pH | 7.5±n/a |
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IC50 | 3.5±n/a nM |
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Comments | extracted |
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Citation | Haas, J; Andrews, SW; Jiang, Y; Zhang, G Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds US Patent US9676783 Publication Date 6/13/2017 |
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More Info.: | Get all data from this article, Assay Method |
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High affinity nerve growth factor receptor [441-796] |
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Name: | High affinity nerve growth factor receptor [441-796] |
Synonyms: | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA) |
Type: | Protein |
Mol. Mass.: | 39939.20 |
Organism: | Homo sapiens (Human) |
Description: | Human his-tagged TrkA cytoplasmic domain (441-796 aa) |
Residue: | 356 |
Sequence: | KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDA
CVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQRE
AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG
PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY
YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI
TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
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BDBM136654 |
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n/a |
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Name | BDBM136654 |
Synonyms: | US10005783, 71 | US10047097, 71 | US10774085, Example 71 | US11267818, Example 71 | US8865698, 71 | US9676783, 71 |
Type | Small organic molecule |
Emp. Form. | C22H17ClF2N6O |
Mol. Mass. | 454.86 |
SMILES | Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cccc(Cl)n3)c2n1 |r| |
Structure |
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