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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336460 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336460 | |||
| n/a | |||
| Name | BDBM336460 | ||
| Synonyms: | US9744172, Compound UNC1148A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H32N6O3S | ||
| Mol. Mass. | 484.614 | ||
| SMILES | CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCC1 |r,wD:15.15,(-7.06,-3.34,;-5.73,-2.57,;-4.4,-3.34,;-3.06,-2.57,;-1.73,-3.34,;-.4,-2.57,;-.4,-1.03,;.94,-.26,;2.27,-1.03,;3.74,-.55,;4.64,-1.8,;3.74,-3.04,;4.14,-4.53,;5.62,-4.93,;6.02,-6.42,;4.93,-7.5,;5.33,-8.99,;3.45,-7.11,;3.05,-5.62,;2.27,-2.57,;.94,-3.34,;4.14,.94,;5.62,1.34,;6.02,2.82,;4.93,3.91,;3.45,3.51,;3.05,2.03,;5.33,5.4,;3.84,5.8,;6.82,5,;5.73,6.89,;7.06,7.66,;6.29,8.99,;4.96,8.22,)| | ||
| Structure | 
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