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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336461 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336461 | |||
| n/a | |||
| Name | BDBM336461 | ||
| Synonyms: | US9744172, Compound UNC1149A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H33FN6O2 | ||
| Mol. Mass. | 468.5669 | ||
| SMILES | CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1 |r,wD:15.15,(-7.29,-3.03,;-5.95,-2.26,;-4.62,-3.03,;-3.29,-2.26,;-1.95,-3.03,;-.62,-2.26,;-.62,-.72,;.72,.05,;2.05,-.72,;3.51,-.24,;4.42,-1.49,;3.51,-2.73,;3.91,-4.22,;5.4,-4.62,;5.8,-6.11,;4.71,-7.2,;5.11,-8.68,;3.22,-6.8,;2.82,-5.31,;2.05,-2.26,;.72,-3.03,;3.91,1.25,;2.82,2.33,;3.22,3.82,;4.71,4.22,;5.11,5.71,;6.6,6.11,;6.99,7.59,;5.91,8.68,;4.42,8.29,;4.02,6.8,;5.8,3.13,;7.29,3.53,;5.4,1.64,)| | ||
| Structure | 
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