| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-1 |
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| Ligand | BDBM322024 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 8.10±n/a nM |
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| Citation |  Beattie, D; Baettig, U; Legrand, DM; Lister, AS; McKenna, J; Pearce, DW; Sandham, DA; Steward, OR; Thomson, C Autotaxin inhibitors US Patent US9763957 Publication Date 9/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-1 |
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| Name: | Ataxin-1 |
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| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
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| Type: | Protein |
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| Mol. Mass.: | 86941.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54253 |
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| Residue: | 815 |
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| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
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| BDBM322024 |
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| n/a |
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| Name | BDBM322024 |
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| Synonyms: | (E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)methyl)phenyl)-1-(4-((4-methyl-2H-1,2,3-triazol-2-yl)methyl)piperidin-1-yl)prop-2-en-1-one | US10183025, Example 120 | US9763957, Example 120 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25ClN8O |
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| Mol. Mass. | 440.929 |
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| SMILES | Cc1cnn(CC2CCN(CC2)C(=O)\C=C\c2ccc(Cl)cc2Cn2nnc(C)n2)n1 |
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| Structure | 
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