Reaction Details |
| Report a problem with these data |
Target | Coagulation factor IX |
---|
Ligand | BDBM352429 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibitory Activity Assay |
---|
IC50 | 550±n/a nM |
---|
Citation | Sakurada, I; Hirabayashi, T; Maeda, Y; Nagasue, H; Mizuno, T; Xu, J; Zhang, T; Smith, C; Parker, D Factor IXa inhibitors US Patent US9808445 Publication Date 11/7/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor IX |
---|
Name: | Coagulation factor IX |
Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
Type: | Enzyme |
Mol. Mass.: | 51768.83 |
Organism: | Homo sapiens (Human) |
Description: | P00740 |
Residue: | 461 |
Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
|
|
|
BDBM352429 |
---|
n/a |
---|
Name | BDBM352429 |
Synonyms: | N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide | US9808445, 7.1 | US9808445, 7.2 |
Type | Small organic molecule |
Emp. Form. | C22H20Cl2N8O2 |
Mol. Mass. | 499.353 |
SMILES | Cc1ncn(n1)-c1ccc(C(=O)N[C@@H]2[C@H]3CC[C@@H]2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |TLB:20:18:16.15:13| |
Structure |
|