Compile Data Set for Download or QSAR

Found 136 hits with Last Name = 'mizuno' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor IX (Rattus norvegicus)	BDBM50240469 (CHEMBL4096341) Show SMILES [H][C@@]12CC[C@]([H])([C@H]1NC(=O)c1ccc(cc1Cl)-n1cnc(C)n1)N(C2)c1ncc(Cl)c2cnoc12 |r,TLB:7:6:23.24:2.3,THB:25:23:6:2.3| Show InChI InChI=1S/C22H19Cl2N7O2/c1-11-26-10-31(29-11)13-3-4-14(16(23)6-13)22(32)28-19-12-2-5-18(19)30(9-12)21-20-15(7-27-33-20)17(24)8-25-21/h3-4,6-8,10,12,18-19H,2,5,9H2,1H3,(H,28,32)/t12-,18+,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of rat coagulation factor 9a				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240469 (CHEMBL4096341) Show SMILES [H][C@@]12CC[C@]([H])([C@H]1NC(=O)c1ccc(cc1Cl)-n1cnc(C)n1)N(C2)c1ncc(Cl)c2cnoc12 |r,TLB:7:6:23.24:2.3,THB:25:23:6:2.3| Show InChI InChI=1S/C22H19Cl2N7O2/c1-11-26-10-31(29-11)13-3-4-14(16(23)6-13)22(32)28-19-12-2-5-18(19)30(9-12)21-20-15(7-27-33-20)17(24)8-25-21/h3-4,6-8,10,12,18-19H,2,5,9H2,1H3,(H,28,32)/t12-,18+,19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240470 (CHEMBL4092982 | US9969724, Example 27) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnc(CCO)c1 |r| Show InChI InChI=1S/C22H21Cl2N7O3/c23-16-7-14(31-9-12(4-6-32)27-11-31)1-2-15(16)22(33)28-13-3-5-30(10-13)21-19-18(17(24)8-26-21)20(25)29-34-19/h1-2,7-9,11,13,32H,3-6,10H2,(H2,25,29)(H,28,33)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240487 (CHEMBL4066380 | US9969724, Example 32) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnc2ncccc12 |r| Show InChI InChI=1S/C23H18Cl2N8O2/c24-15-8-13(33-11-29-21-17(33)2-1-6-27-21)3-4-14(15)23(34)30-12-5-7-32(10-12)22-19-18(16(25)9-28-22)20(26)31-35-19/h1-4,6,8-9,11-12H,5,7,10H2,(H2,26,31)(H,30,34)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240471 (CHEMBL4069082 | US9969724, Example 45) Show SMILES Cn1ncn(-c2ccc(C(=O)N[C@@H]3CCN(C3)c3ncc(Cl)c4c(N)noc34)c(Cl)c2)c1=O |r| Show InChI InChI=1S/C20H18Cl2N8O3/c1-28-20(32)30(9-25-28)11-2-3-12(13(21)6-11)19(31)26-10-4-5-29(8-10)18-16-15(14(22)7-24-18)17(23)27-33-16/h2-3,6-7,9-10H,4-5,8H2,1H3,(H2,23,27)(H,26,31)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240472 (CHEMBL4090664) Show SMILES Nc1noc2c(cc(Cl)cc12)N1CCC(C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C20H17Cl2N7O2/c21-11-5-15-18(31-27-19(15)23)17(6-11)28-4-3-12(8-28)26-20(30)14-2-1-13(7-16(14)22)29-9-24-25-10-29/h1-2,5-7,9-10,12H,3-4,8H2,(H2,23,27)(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240473 (CHEMBL4095415) Show SMILES Cn1cc(ccc1=O)-c1ccc(C(=O)N[C@@H]2CCN(C2)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |r| Show InChI InChI=1S/C23H20Cl2N6O3/c1-30-10-13(3-5-18(30)32)12-2-4-15(16(24)8-12)23(33)28-14-6-7-31(11-14)22-20-19(17(25)9-27-22)21(26)29-34-20/h2-5,8-10,14H,6-7,11H2,1H3,(H2,26,29)(H,28,33)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against purified human renal renin at pH 6.5				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240489 (CHEMBL4101793 | US9969724, Example 20) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-c1cncnc1 |r| Show InChI InChI=1S/C21H17Cl2N7O2/c22-15-5-11(12-6-25-10-26-7-12)1-2-14(15)21(31)28-13-3-4-30(9-13)20-18-17(16(23)8-27-20)19(24)29-32-18/h1-2,5-8,10,13H,3-4,9H2,(H2,24,29)(H,28,31)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240474 (CHEMBL4082857) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 |r| Show InChI InChI=1S/C19H16Cl2N8O2/c20-13-5-11(29-8-24-25-9-29)1-2-12(13)19(30)26-10-3-4-28(7-10)18-16-15(14(21)6-23-18)17(22)27-31-16/h1-2,5-6,8-10H,3-4,7H2,(H2,22,27)(H,26,30)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240476 (CHEMBL4087720 | US9969724, Example 29) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnc2ccccc12 |r| Show InChI InChI=1S/C24H19Cl2N7O2/c25-16-9-14(33-12-29-18-3-1-2-4-19(18)33)5-6-15(16)24(34)30-13-7-8-32(11-13)23-21-20(17(26)10-28-23)22(27)31-35-21/h1-6,9-10,12-13H,7-8,11H2,(H2,27,31)(H,30,34)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240475 (CHEMBL4080361 | US9969724, Example 9) Show SMILES Nc1noc2c(ccc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 |r| Show InChI InChI=1S/C20H17Cl2N7O2/c21-14-3-4-16(18-17(14)19(23)27-31-18)28-6-5-11(8-28)26-20(30)13-2-1-12(7-15(13)22)29-9-24-25-10-29/h1-4,7,9-11H,5-6,8H2,(H2,23,27)(H,26,30)/t11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240491 (CHEMBL4065316 | US9969724, Example 11) Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |r| Show InChI InChI=1S/C20H18Cl2N8O2/c1-10-25-9-30(27-10)12-2-3-13(14(21)6-12)20(31)26-11-4-5-29(8-11)19-17-16(15(22)7-24-19)18(23)28-32-17/h2-3,6-7,9,11H,4-5,8H2,1H3,(H2,23,28)(H,26,31)/t11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240477 (CHEMBL4074983 | US9969724, Example 44) Show SMILES Cn1cc(cnc1=O)-c1ccc(C(=O)N[C@@H]2CCN(C2)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |r| Show InChI InChI=1S/C22H19Cl2N7O3/c1-30-9-12(7-27-22(30)33)11-2-3-14(15(23)6-11)21(32)28-13-4-5-31(10-13)20-18-17(16(24)8-26-20)19(25)29-34-18/h2-3,6-9,13H,4-5,10H2,1H3,(H2,25,29)(H,28,32)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240478 (CHEMBL4083789) Show SMILES Cc1cc2c(N)noc2c(n1)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 |r| Show InChI InChI=1S/C20H19ClN8O2/c1-11-6-15-17(31-27-18(15)22)19(25-11)28-5-4-12(8-28)26-20(30)14-3-2-13(7-16(14)21)29-9-23-24-10-29/h2-3,6-7,9-10,12H,4-5,8H2,1H3,(H2,22,27)(H,26,30)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240493 (CHEMBL4085239 | US9969724, Example 28) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1C(F)F |r| Show InChI InChI=1S/C20H16Cl2F2N8O2/c21-12-5-10(32-8-27-29-19(32)16(23)24)1-2-11(12)20(33)28-9-3-4-31(7-9)18-15-14(13(22)6-26-18)17(25)30-34-15/h1-2,5-6,8-9,16H,3-4,7H2,(H2,25,30)(H,28,33)/t9-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240479 (CHEMBL4072364 | US9969724, Example 14) Show SMILES Nc1noc2c(cc(Cl)c(Cl)c12)N1CC[C@H](C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 |r| Show InChI InChI=1S/C20H16Cl3N7O2/c21-13-5-11(30-8-25-26-9-30)1-2-12(13)20(31)27-10-3-4-29(7-10)15-6-14(22)17(23)16-18(15)32-28-19(16)24/h1-2,5-6,8-10H,3-4,7H2,(H2,24,28)(H,27,31)/t10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240482 (CHEMBL4069648) Show SMILES Cc1cc(N2CCC(C2)NC(=O)c2ccc(cc2Cl)-n2cnnc2)c2onc(N)c2c1 Show InChI InChI=1S/C21H20ClN7O2/c1-12-6-16-19(31-27-20(16)23)18(7-12)28-5-4-13(9-28)26-21(30)15-3-2-14(8-17(15)22)29-10-24-25-11-29/h2-3,6-8,10-11,13H,4-5,9H2,1H3,(H2,23,27)(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240483 (CHEMBL4099310 | US9969724, Example 12) Show SMILES Cc1cc(N2CC[C@H](C2)NC(=O)c2ccc(cc2Cl)-n2cnnc2)c2onc(N)c2c1Cl |r| Show InChI InChI=1S/C21H19Cl2N7O2/c1-11-6-16(19-17(18(11)23)20(24)28-32-19)29-5-4-12(8-29)27-21(31)14-3-2-13(7-15(14)22)30-9-25-26-10-30/h2-3,6-7,9-10,12H,4-5,8H2,1H3,(H2,24,28)(H,27,31)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240488 (CHEMBL4060976 | US9969724, Example 5) Show SMILES Nc1noc2c(nccc12)N1CCC(C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C19H17ClN8O2/c20-15-7-12(28-9-23-24-10-28)1-2-13(15)19(29)25-11-4-6-27(8-11)18-16-14(3-5-22-18)17(21)26-30-16/h1-3,5,7,9-11H,4,6,8H2,(H2,21,26)(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assay				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240484 (CHEMBL4085322 | US9969724, Example 1) Show SMILES Nc1noc2c(cccc12)N1CCC(C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C20H18ClN7O2/c21-16-8-13(28-10-23-24-11-28)4-5-14(16)20(29)25-12-6-7-27(9-12)17-3-1-2-15-18(17)30-26-19(15)22/h1-5,8,10-12H,6-7,9H2,(H2,22,26)(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Mochida Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human plasma renin at pH 7.4				Bioorg Med Chem Lett 27: 2622-2628 (2017) Article DOI: 10.1016/j.bmcl.2017.03.002 BindingDB Entry DOI: 10.7270/Q28054RH
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352434 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES COc1ncc(cn1)-c1ccc(C(=O)NC2C3CCC2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C24H21Cl2N7O3/c1-35-24-29-7-13(8-30-24)11-2-4-14(15(25)6-11)23(34)31-19-12-3-5-17(19)33(10-12)22-20-18(16(26)9-28-22)21(27)32-36-20/h2,4,6-9,12,17,19H,3,5,10H2,1H3,(H2,27,32)(H,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352435 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-...) Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@H]2[C@H]3CC[C@@H]2N(C3)c2nc(C)cc3c(N)noc23)c(Cl)c1 |TLB:20:18:16.15:13| Show InChI InChI=1S/C23H23ClN8O2/c1-11-7-16-20(34-30-21(16)25)22(27-11)31-9-13-3-6-18(31)19(13)28-23(33)15-5-4-14(8-17(15)24)32-10-26-12(2)29-32/h4-5,7-8,10,13,18-19H,3,6,9H2,1-2H3,(H2,25,30)(H,28,33)/t13-,18-,19+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352437 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1ccnnc1 Show InChI InChI=1S/C23H19Cl2N7O2/c24-15-7-11(12-5-6-28-29-8-12)1-3-14(15)23(33)30-19-13-2-4-17(19)32(10-13)22-20-18(16(25)9-27-22)21(26)31-34-20/h1,3,5-9,13,17,19H,2,4,10H2,(H2,26,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352438 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1)-n1cnnc1 Show InChI InChI=1S/C21H19ClN8O2/c22-14-7-24-20(18-16(14)19(23)28-32-18)30-8-12-3-6-15(30)17(12)27-21(31)11-1-4-13(5-2-11)29-9-25-26-10-29/h1-2,4-5,7,9-10,12,15,17H,3,6,8H2,(H2,23,28)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352439 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnc(CCO)c1 Show InChI InChI=1S/C24H23Cl2N7O3/c25-16-7-14(32-10-13(5-6-34)29-11-32)2-3-15(16)24(35)30-20-12-1-4-18(20)33(9-12)23-21-19(17(26)8-28-23)22(27)31-36-21/h2-3,7-8,10-12,18,20,34H,1,4-6,9H2,(H2,27,31)(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352440 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-...) Show SMILES Cc1cc2c(N)noc2c(n1)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cc(CCO)nn1 Show InChI InChI=1S/C24H25ClN8O3/c1-12-8-17-21(36-30-22(17)26)23(27-12)32-10-13-2-5-19(32)20(13)28-24(35)16-4-3-15(9-18(16)25)33-11-14(6-7-34)29-31-33/h3-4,8-9,11,13,19-20,34H,2,5-7,10H2,1H3,(H2,26,30)(H,28,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352441 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1C(F)F Show InChI InChI=1S/C22H18Cl2F2N8O2/c23-12-5-10(34-8-29-31-21(34)18(25)26)2-3-11(12)22(35)30-16-9-1-4-14(16)33(7-9)20-17-15(13(24)6-28-20)19(27)32-36-17/h2-3,5-6,8-9,14,16,18H,1,4,7H2,(H2,27,32)(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352442 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-...) Show SMILES Cc1cc2c(N)noc2c(n1)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1cnc(nc1)C#N Show InChI InChI=1S/C25H21ClN8O2/c1-12-6-17-22(36-33-23(17)28)24(31-12)34-11-14-3-5-19(34)21(14)32-25(35)16-4-2-13(7-18(16)26)15-9-29-20(8-27)30-10-15/h2,4,6-7,9-10,14,19,21H,3,5,11H2,1H3,(H2,28,33)(H,32,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352443 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Cn1cc(ccc1=O)-c1ccc(C(=O)NC2C3CCC2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C25H22Cl2N6O3/c1-32-10-13(4-7-19(32)34)12-2-5-15(16(26)8-12)25(35)30-21-14-3-6-18(21)33(11-14)24-22-20(17(27)9-29-24)23(28)31-36-22/h2,4-5,7-10,14,18,21H,3,6,11H2,1H3,(H2,28,31)(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352444 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1ccc(=O)n(c1)C(F)F Show InChI InChI=1S/C25H20Cl2F2N6O3/c26-15-7-11(12-3-6-18(36)35(9-12)25(28)29)1-4-14(15)24(37)32-20-13-2-5-17(20)34(10-13)23-21-19(16(27)8-31-23)22(30)33-38-21/h1,3-4,6-9,13,17,20,25H,2,5,10H2,(H2,30,33)(H,32,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352445 (4-([1,2,4]Triazolo[4,3-a]pyridin-6-yl)-N-((1S*,4S*...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1ccc2nncn2c1 Show InChI InChI=1S/C25H20Cl2N8O2/c26-16-7-12(13-3-6-19-32-30-11-34(19)9-13)1-4-15(16)25(36)31-21-14-2-5-18(21)35(10-14)24-22-20(17(27)8-29-24)23(28)33-37-22/h1,3-4,6-9,11,14,18,21H,2,5,10H2,(H2,28,33)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352446 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnc2ccccc12 Show InChI InChI=1S/C26H21Cl2N7O2/c27-16-9-14(35-12-31-18-3-1-2-4-19(18)35)6-7-15(16)26(36)32-22-13-5-8-20(22)34(11-13)25-23-21(17(28)10-30-25)24(29)33-37-23/h1-4,6-7,9-10,12-13,20,22H,5,8,11H2,(H2,29,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352447 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnc2ncccc12 Show InChI InChI=1S/C25H20Cl2N8O2/c26-15-8-13(35-11-31-23-18(35)2-1-7-29-23)4-5-14(15)25(36)32-20-12-3-6-17(20)34(10-12)24-21-19(16(27)9-30-24)22(28)33-37-21/h1-2,4-5,7-9,11-12,17,20H,3,6,10H2,(H2,28,33)(H,32,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352448 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1ccc(=O)n(CCO)c1 Show InChI InChI=1S/C26H24Cl2N6O4/c27-17-9-13(14-3-6-20(36)33(11-14)7-8-35)1-4-16(17)26(37)31-22-15-2-5-19(22)34(12-15)25-23-21(18(28)10-30-25)24(29)32-38-23/h1,3-4,6,9-11,15,19,22,35H,2,5,7-8,12H2,(H2,29,32)(H,31,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352449 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Cn1nc(ccc1=O)-c1ccc(C(=O)NC2C3CCC2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C24H21Cl2N7O3/c1-32-18(34)7-5-16(30-32)11-2-4-13(14(25)8-11)24(35)29-20-12-3-6-17(20)33(10-12)23-21-19(15(26)9-28-23)22(27)31-36-21/h2,4-5,7-9,12,17,20H,3,6,10H2,1H3,(H2,27,31)(H,29,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352450 (N-((1S*,4S*,7R*)-2-(3-Amino-5-cyanoisoxazolo[5,4-c...) Show SMILES Cn1cc(ccc1=O)-c1ccc(C(=O)NC2C3CCC2N(C3)c2nc(cc3c(N)noc23)C#N)c(Cl)c1 Show InChI InChI=1S/C26H22ClN7O3/c1-33-11-14(4-7-21(33)35)13-2-5-17(19(27)8-13)26(36)31-22-15-3-6-20(22)34(12-15)25-23-18(24(29)32-37-23)9-16(10-28)30-25/h2,4-5,7-9,11,15,20,22H,3,6,12H2,1H3,(H2,29,32)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352451 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-...) Show SMILES Cc1cc2c(N)noc2c(n1)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1C(F)(F)F Show InChI InChI=1S/C23H20ClF3N8O2/c1-10-6-14-18(37-33-19(14)28)20(30-10)34-8-11-2-5-16(34)17(11)31-21(36)13-4-3-12(7-15(13)24)35-9-29-32-22(35)23(25,26)27/h3-4,6-7,9,11,16-17H,2,5,8H2,1H3,(H2,28,33)(H,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352452 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-...) Show SMILES Cc1cc2c(N)noc2c(n1)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1cnc(=O)n(C)c1 Show InChI InChI=1S/C25H24ClN7O3/c1-12-7-17-21(36-31-22(17)27)23(29-12)33-11-14-4-6-19(33)20(14)30-24(34)16-5-3-13(8-18(16)26)15-9-28-25(35)32(2)10-15/h3,5,7-10,14,19-20H,4,6,11H2,1-2H3,(H2,27,31)(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352453 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Cn1ncn(-c2ccc(C(=O)NC3C4CCC3N(C4)c3ncc(Cl)c4c(N)noc34)c(Cl)c2)c1=O Show InChI InChI=1S/C22H20Cl2N8O3/c1-30-22(34)32(9-27-30)11-3-4-12(13(23)6-11)21(33)28-17-10-2-5-15(17)31(8-10)20-18-16(14(24)7-26-20)19(25)29-35-18/h3-4,6-7,9-10,15,17H,2,5,8H2,1H3,(H2,25,29)(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352454 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Cc1ncn(n1)-c1cnc(C(=O)N[C@@H]2[C@H]3CC[C@@H]2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |TLB:20:18:16.15:13| Show InChI InChI=1S/C21H19Cl2N9O2/c1-9-27-8-32(29-9)11-4-12(22)17(25-5-11)21(33)28-16-10-2-3-14(16)31(7-10)20-18-15(13(23)6-26-20)19(24)30-34-18/h4-6,8,10,14,16H,2-3,7H2,1H3,(H2,24,30)(H,28,33)/t10-,14-,16+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352422 (N-((1S*,4S*, 7R*)-2-(3-Aminobenzo[d]isoxazol-7-yl)...) Show SMILES Nc1noc2c(cccc12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C22H20ClN7O2/c23-16-8-13(29-10-25-26-11-29)5-6-14(16)22(31)27-19-12-4-7-17(19)30(9-12)18-3-1-2-15-20(18)32-28-21(15)24/h1-3,5-6,8,10-12,17,19H,4,7,9H2,(H2,24,28)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352423 (N-((1S*,4S*,7R*)-2-(3-Aminoisoxazolo[5,4-c]pyridin...) Show SMILES Cc1ncn(n1)-c1ccc(C(=O)NC2C3CCC2N(C3)c2nccc3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C22H21ClN8O2/c1-11-26-10-31(28-11)13-3-4-14(16(23)8-13)22(32)27-18-12-2-5-17(18)30(9-12)21-19-15(6-7-25-21)20(24)29-33-19/h3-4,6-8,10,12,17-18H,2,5,9H2,1H3,(H2,24,29)(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352424 (N-((1S*,4S*,7R*)-2-(3-Amino-5-methylbenzo[d]isoxaz...) Show SMILES Cc1ncn(n1)-c1cc(Cl)c(C(=O)NC2C3CCC2N(C3)c2cc(C)cc3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C24H23Cl2N7O2/c1-11-5-15-22(35-31-23(15)27)19(6-11)32-9-13-3-4-18(32)21(13)29-24(34)20-16(25)7-14(8-17(20)26)33-10-28-12(2)30-33/h5-8,10,13,18,21H,3-4,9H2,1-2H3,(H2,27,31)(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352425 (N-((1S*,4S*,7R*)-2-(3-Amino-5-chlorobenzo[d]isoxaz...) Show SMILES Cc1ncn(n1)-c1ccc(C(=O)NC2C3CCC2N(C3)c2cc(Cl)cc3c(N)noc23)c(Cl)c1 Show InChI InChI=1S/C23H21Cl2N7O2/c1-11-27-10-32(29-11)14-3-4-15(17(25)8-14)23(33)28-20-12-2-5-18(20)31(9-12)19-7-13(24)6-16-21(19)34-30-22(16)26/h3-4,6-8,10,12,18,20H,2,5,9H2,1H3,(H2,26,30)(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352427 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chlorobenzo[d]isoxaz...) Show SMILES Nc1noc2c(ccc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C22H19Cl2N7O2/c23-14-4-6-17(20-18(14)21(25)29-33-20)31-8-11-1-5-16(31)19(11)28-22(32)13-3-2-12(7-15(13)24)30-9-26-27-10-30/h2-4,6-7,9-11,16,19H,1,5,8H2,(H2,25,29)(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352428 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C21H18Cl2N8O2/c22-13-5-11(30-8-26-27-9-30)2-3-12(13)21(32)28-17-10-1-4-15(17)31(7-10)20-18-16(14(23)6-25-20)19(24)29-33-18/h2-3,5-6,8-10,15,17H,1,4,7H2,(H2,24,29)(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352429 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@H]2[C@H]3CC[C@@H]2N(C3)c2ncc(Cl)c3c(N)noc23)c(Cl)c1 |TLB:20:18:16.15:13| Show InChI InChI=1S/C22H20Cl2N8O2/c1-10-27-9-32(29-10)12-3-4-13(14(23)6-12)22(33)28-18-11-2-5-16(18)31(8-11)21-19-17(15(24)7-26-21)20(25)30-34-19/h3-4,6-7,9,11,16,18H,2,5,8H2,1H3,(H2,25,30)(H,28,33)/t11-,16-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Coagulation factor IX (Homo sapiens (Human))	BDBM352431 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cncn1 |TLB:5:11:17:14.15| Show InChI InChI=1S/C21H18Cl2N8O2/c22-13-5-11(31-9-25-8-27-31)2-3-12(13)21(32)28-17-10-1-4-15(17)30(7-10)20-18-16(14(23)6-26-20)19(24)29-33-18/h2-3,5-6,8-10,15,17H,1,4,7H2,(H2,24,29)(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM352433 (N-((1S*,4S*,7R*)-2-(3-Amino-4-chloroisoxazolo[5,4-...) Show SMILES Nc1noc2c(ncc(Cl)c12)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-c1cncnc1 |TLB:5:11:17:14.15| Show InChI InChI=1S/C23H19Cl2N7O2/c24-15-5-11(13-6-27-10-28-7-13)1-3-14(15)23(33)30-19-12-2-4-17(19)32(9-12)22-20-18(16(25)8-29-22)21(26)31-34-20/h1,3,5-8,10,12,17,19H,2,4,9H2,(H2,26,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp.; Mochida Pharmaceutical Co., Ltd. US Patent					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				US Patent US9808445 (2017) BindingDB Entry DOI: 10.7270/Q28G8NV1
					More data for this Ligand-Target Pair
Coagulation factor IX (Homo sapiens (Human))	BDBM50240484 (CHEMBL4085322 | US9969724, Example 1) Show SMILES Nc1noc2c(cccc12)N1CCC(C1)NC(=O)c1ccc(cc1Cl)-n1cnnc1 Show InChI InChI=1S/C20H18ClN7O2/c21-16-8-13(28-10-23-24-11-28)4-5-14(16)20(29)25-12-6-7-27(9-12)17-3-1-2-15-18(17)30-26-19(15)22/h1-5,8,10-12H,6-7,9H2,(H2,22,26)(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...				J Med Chem 52: 2818-24 (2009) BindingDB Entry DOI: 10.7270/Q2WQ063R
					More data for this Ligand-Target Pair

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