Reaction Details |
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Target | Tyrosine--tRNA ligase |
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Ligand | BDBM18131 |
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Substrate/Competitor | BDBM18129 |
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Meas. Tech. | Tyrosyl tRNA Synthetase Inhibition Assay |
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pH | 7.9±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 0.2±n/a nM |
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Citation | Qiu, X; Janson, CA; Smith, WW; Green, SM; McDevitt, P; Johanson, K; Carter, P; Hibbs, M; Lewis, C; Chalker, A; Fosberry, A; Lalonde, J; Berge, J; Brown, P; Houge-Frydrych, CS; Jarvest, RL Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci10:2008-16 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine--tRNA ligase |
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Name: | Tyrosine--tRNA ligase |
Synonyms: | SYY_STAA8 | Tyrosine--tRNA ligase | tRNA synthetase (TyrRS) | tyrS |
Type: | Enzyme |
Mol. Mass.: | 47586.43 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 420 |
Sequence: | MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
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BDBM18131 |
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BDBM18129 |
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Name | BDBM18131 |
Synonyms: | SB-243545 | butyl (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-4-(hydroxymethyl)piperidin-2-yl]acetate |
Type | Small organic molecule |
Emp. Form. | C21H33N3O9 |
Mol. Mass. | 471.5014 |
SMILES | [H][C@]1([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)OCCCC)[C@H](O)[C@](O)(CO)[C@@H](O)CN1O |r| |
Structure |
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