Reaction Details |
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Target | Tyrosine--tRNA ligase |
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Ligand | BDBM18132 |
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Substrate/Competitor | BDBM18129 |
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Meas. Tech. | Tyrosyl tRNA Synthetase Inhibition Assay |
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pH | 7.9±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 4±n/a nM |
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Citation | Qiu, X; Janson, CA; Smith, WW; Green, SM; McDevitt, P; Johanson, K; Carter, P; Hibbs, M; Lewis, C; Chalker, A; Fosberry, A; Lalonde, J; Berge, J; Brown, P; Houge-Frydrych, CS; Jarvest, RL Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci10:2008-16 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine--tRNA ligase |
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Name: | Tyrosine--tRNA ligase |
Synonyms: | SYY_STAA8 | Tyrosine--tRNA ligase | tRNA synthetase (TyrRS) | tyrS |
Type: | Enzyme |
Mol. Mass.: | 47586.43 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 420 |
Sequence: | MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
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BDBM18132 |
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BDBM18129 |
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Name | BDBM18132 |
Synonyms: | (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]acetic acid | CHEMBL163022 | SB-284485 |
Type | Small organic molecule |
Emp. Form. | C17H24N2O8 |
Mol. Mass. | 384.3811 |
SMILES | [H][C@]1(O[C@H](C)[C@H](O)[C@H](O)[C@H]1O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O |r| |
Structure |
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