| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
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| Ligand | BDBM105879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LSD1 Histone Demethylase Biochemical Assay |
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| pH | 7.5±n/a |
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| IC50 | <50±n/a nM |
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| Comments | extracted |
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| Citation |  Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Imidazopyridines and imidazopyrazines as LSD1 inhibitors US Patent US10047086 Publication Date 8/14/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A |
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| Name: | Lysine-specific histone demethylase 1A |
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| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 92901.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60341 |
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| Residue: | 852 |
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| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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| BDBM105879 |
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| n/a |
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| Name | BDBM105879 |
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| Synonyms: | US10047086, 138 | US10640503, Example 138 | US9695168, 138 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29FN8O |
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| Mol. Mass. | 524.592 |
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| SMILES | CN(C)C1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2cc(F)c3n(C)c(=O)n(C)c3c2)n2cncc12 |
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| Structure | 
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