| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM26518 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 1300±n/a nM |
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| Citation |  Beierlein, JM; Frey, KM; Bolstad, DB; Pelphrey, PM; Joska, TM; Smith, AE; Priestley, ND; Wright, DL; Anderson, AC Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase. J Med Chem51:7532-40 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM26518 |
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| BDBM18044 |
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| Name | BDBM26518 |
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| Synonyms: | 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | Propargyl inhibitor, 16 | Propargyl-linked, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N4O2 |
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| Mol. Mass. | 298.3397 |
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| SMILES | COc1ccc(OC)c(CC#Cc2c(C)nc(N)nc2N)c1 |
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| Structure | 
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