| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM28815 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 293.15±n/a K |
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| IC50 | 780±250 nM |
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| Citation |  Gujjar, R; Marwaha, A; El Mazouni, F; White, J; White, KL; Creason, S; Shackleford, DM; Baldwin, J; Charman, WN; Buckner, FS; Charman, S; Rathod, PK; Phillips, MA Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem52:1864-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 65581.88 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Q08210 |
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| Residue: | 569 |
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| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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| BDBM28815 |
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| BDBM14700 |
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| Name | BDBM28815 |
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| Synonyms: | N-(4-bromophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | triazolopyrimidine-based compound, DSM98 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10BrN5 |
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| Mol. Mass. | 304.145 |
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| SMILES | Cc1cc(Nc2ccc(Br)cc2)n2ncnc2n1 |
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| Structure | 
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