Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase JAK3 [781-1124] |
---|
Ligand | BDBM264218 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | JAK Enzymatic Assay |
---|
pH | 7.3±n/a |
---|
IC50 | >30000±n/a nM |
---|
Comments | extracted |
---|
Citation | Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK3 [781-1124] |
---|
Name: | Tyrosine-protein kinase JAK3 [781-1124] |
Synonyms: | JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124) |
Type: | n/a |
Mol. Mass.: | 38772.27 |
Organism: | Homo sapiens (Human) |
Description: | P52333[781-1124] |
Residue: | 344 |
Sequence: | ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
|
|
|
BDBM264218 |
---|
n/a |
---|
Name | BDBM264218 |
Synonyms: | (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy- 1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4- yl}-1H-indol-7- yl)propanamide | US10167276, Example 38 | US10654835, Example 38 | US11247983, Example 38 | US9714236, 38 |
Type | Small organic molecule |
Emp. Form. | C27H35N9O2 |
Mol. Mass. | 517.6259 |
SMILES | COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| |
Structure |
|