Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase JAK3 [781-1124] |
---|
Ligand | BDBM264233 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | JAK Enzymatic Assay |
---|
pH | 7.3±n/a |
---|
IC50 | >30000±n/a nM |
---|
Comments | extracted |
---|
Citation | Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK3 [781-1124] |
---|
Name: | Tyrosine-protein kinase JAK3 [781-1124] |
Synonyms: | JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124) |
Type: | n/a |
Mol. Mass.: | 38772.27 |
Organism: | Homo sapiens (Human) |
Description: | P52333[781-1124] |
Residue: | 344 |
Sequence: | ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
|
|
|
BDBM264233 |
---|
n/a |
---|
Name | BDBM264233 |
Synonyms: | (2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amino]-5- fluoropyimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 53 | US10654835, Example 53 | US11247983, Example 53 | US9714236, 53 |
Type | Small organic molecule |
Emp. Form. | C26H32FN9O2 |
Mol. Mass. | 521.5898 |
SMILES | COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1F |r| |
Structure |
|