Reaction Details |
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Target | Tyrosine-protein kinase JAK3 [781-1124] |
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Ligand | BDBM264244 |
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Substrate/Competitor | n/a |
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Meas. Tech. | JAK Enzymatic Assay |
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pH | 7.3±n/a |
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IC50 | >30000±n/a nM |
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Comments | extracted |
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Citation | Grimster, N; Kawatkar, S; Kettle, JG; Su, Q; Vasbinder, M; Chuaqui, CE Compounds and methods for inhibiting JAK US Patent US9714236 Publication Date 7/25/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK3 [781-1124] |
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Name: | Tyrosine-protein kinase JAK3 [781-1124] |
Synonyms: | JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124) |
Type: | n/a |
Mol. Mass.: | 38772.27 |
Organism: | Homo sapiens (Human) |
Description: | P52333[781-1124] |
Residue: | 344 |
Sequence: | ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
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BDBM264244 |
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n/a |
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Name | BDBM264244 |
Synonyms: | (2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)-3-methoxy- 2-(4-methylpiperazin-1- yl)propanamide | US9714236, 64 |
Type | Small organic molecule |
Emp. Form. | C28H37N9O3 |
Mol. Mass. | 547.6519 |
SMILES | CCOc1nn(C)cc1Nc1cnc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12 |r| |
Structure |
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