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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apelin receptor | ||
| Ligand | BDBM269513 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | [35S]GTPgammaS Binding Assay | ||
| pH | 7.5±n/a | ||
| EC50 | 830±n/a nM | ||
| Comments | extracted | ||
| Citation |  Chen, N; Chen, X; Chen, Y; Fu, Z; Heath, JA; Horne, DB; Kaller, MR; Khakoo, AY; Kopecky, DJ; Ma, Z; Mihalic, JT; Swaminath, G; Wang, X; Yeh, W Methods of treating heart failure US Patent US10058550 Publication Date 8/28/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apelin receptor | |||
| Name: | Apelin receptor | ||
| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 42664.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35414 | ||
| Residue: | 380 | ||
| Sequence: |
| ||
| BDBM269513 | |||
| n/a | |||
| Name | BDBM269513 | ||
| Synonyms: | N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyridinyl)-4H-1,2,4-triazol-3-yl)ethanesulfonamide | US10058550, Example 30.0 | US10221162, Example 30.0 | US9845310, Example 30.0 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21N5O4S | ||
| Mol. Mass. | 403.455 | ||
| SMILES | CCS(=O)(=O)Nc1nnc(-c2cccc(C)n2)n1-c1c(OC)cccc1OC |(5.82,.28,;5.82,-1.26,;4.49,-2.03,;3.72,-3.36,;5.26,-3.36,;3.16,-1.26,;1.82,-2.03,;1.35,-3.49,;-.19,-3.49,;-.67,-2.03,;-2.16,-1.63,;-2.56,-.14,;-4.04,.25,;-5.13,-.83,;-4.73,-2.32,;-5.82,-3.41,;-3.25,-2.72,;.58,-1.13,;.58,.41,;1.91,1.18,;3.24,.41,;4.58,1.18,;1.91,2.72,;.58,3.49,;-.76,2.72,;-.76,1.18,;-2.09,.41,;-3.43,1.18,)| | ||
| Structure | 
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