Reaction Details | |||
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Target | Lysine-specific histone demethylase 1A [151-852] | ||
Ligand | BDBM105597 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Demethylase Biochemical Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <50±n/a nM | ||
Comments | extracted | ||
Citation | Wu, L; Konkol, LC; Lajkiewicz, N; Lu, L; Xu, M; Yao, W; Yu, Z; Zhang, C; He, C Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors US Patent US9695168 Publication Date 7/4/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A [151-852] | |||
Name: | Lysine-specific histone demethylase 1A [151-852] | ||
Synonyms: | AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A | ||
Type: | n/a | ||
Mol. Mass.: | 77867.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ENZO (BML-SE544-0050) which consists of 151-852 aa | ||
Residue: | 702 | ||
Sequence: |
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BDBM105597 | |||
n/a | |||
Name | BDBM105597 | ||
Synonyms: | US10047086, 111 | US10640503, Example 111 | US9695168, 111 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H27FN6O3 | ||
Mol. Mass. | 526.5615 | ||
SMILES | CCN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc4oc(=O)n(C)c4cc3F)n3cncc23)C1 |r,wD:6.6,(9.96,1.67,;8.62,.9,;7.29,1.67,;7.29,3.21,;5.96,3.98,;4.62,3.21,;4.62,1.67,;3.29,.9,;1.95,1.67,;.62,.9,;-.71,1.67,;-2.05,.9,;-3.38,1.67,;-3.38,3.21,;-4.71,3.98,;-6.05,3.21,;-6.05,1.67,;-4.71,.9,;-7.38,3.98,;-8.71,4.75,;-2.05,-.64,;-3.38,-1.41,;-4.71,-.64,;-6.05,-1.41,;-7.51,-.93,;-8.42,-2.18,;-9.96,-2.18,;-7.51,-3.42,;-8.28,-4.75,;-6.05,-2.95,;-4.71,-3.72,;-3.38,-2.95,;-2.05,-3.72,;-.71,-1.41,;-.39,-2.91,;1.14,-3.07,;1.77,-1.67,;.62,-.64,;5.96,.9,)| | ||
Structure |