| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-III |
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| Ligand | BDBM50239861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667494 (CHEMBL4017290) |
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| IC50 | 32000±n/a nM |
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| Citation |  Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem60:5759-5771 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-III |
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| Name: | Eukaryotic initiation factor 4A-III |
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| Synonyms: | ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265 |
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| Type: | Protein |
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| Mol. Mass.: | 46871.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P38919 |
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| Residue: | 411 |
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| Sequence: | MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
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| BDBM50239861 |
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| n/a |
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| Name | BDBM50239861 |
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| Synonyms: | CHEMBL4092701 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20N4O4S |
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| Mol. Mass. | 448.494 |
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| SMILES | OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| |
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| Structure | 
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